Molecular Foundry Seminar

"Functional Lipid Nanostructures Assembled by Dip-Pen Nanolithography"

Professor Steven Lenhert, Department of Biological Science and Integrative Nanoscience Institute,
The Florida State University
Tuesday, January 18th at 1:30 pm, Bldg. 67 - 3111

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Abstract:

Phospholipids form the structural and functional basis of biological membranes, which are made possible by their tendency to self-organize in water to form lipid bilayer membranes. The reconstruction of functional lipid nanostructures is therefore an active field. Parallel and multiplexed dip-pen nanolithography (DPN) using phospholipids is particularly well suited for this purpose, as it is allows multiple lipid materials to be integrated over large surface areas, with submicron lateral resolution.[1,2] In particular, optical diffraction gratings composed of fluid phospholipids structured on the scale of the wavelength of visible light give rise to phospholipid based materials with structurally tunable optical properties. These biometamaterials can be used for label free biosensing, as model systems for cell adhesion, and general investigations into liposome function.[3]

References:

[1] Lenhert, S., Sun, P., Wang, Y.H., Fuchs, H., and Mirkin, C.A. (2007). Massively parallel dip-pen nanolithography of heterogeneous supported phospholipid multilayer patterns. Small 3, 71-75.

[2] Sekula, S., Fuchs, J., Weg-Remers, S., Nagel, P., Schuppler, S., Fragala, J., Theilacker, N., Franzreb, M., Wingren, C., Ellmark, P., Borrebaeck, C. A. K., Mirkin, C. A., Fuchs H., and S. Lenhert (2008). Multiplexed lipid dip-pen nanolithography on subcellular scales for templating of functional proteins and cell culture. Small 4, 1785 - 1793.

[3] Lenhert, S., Brinkmann, F., Laue, T., Walheim, S., Vannahme, C., Klinkhammer, S., Xu, M., Sekula, S., Mappes, T., Schimmel, T., and Fuchs H. (2010). Lipid multilayer gratings. Nature Nanotechnology 5, 275 - 279.