« Foundry Home Page

Date: Tuesday, April 15, 2014
Time: 11:00 am
Speaker: Prof. Korin Wheeler Santa Clara University
Title: Evaluation of the Role of Proteins in the Environmental Fate and Reactivity of Nanomaterials
Location: 67-3111 Chemla Room

Hosted by Jim Schuck

The safe and sustainable use engineered nanoparticles (NPs) will not be possible until between the structure of NPs and the reactivity with molecules in the environment is better understood. Proteins encountered in biological and environmental systems play a dominant role in altering and controlling the surface chemistry of NPs. We present results from a two-pronged approach that examining two different types of protein interactions with NPs. In the first, a small library of loosely associated, rapidly exchanging proteins are examined for catalysis of reactions at the NP surface. Second, we use MS proteomics approaches to analyze slowly exchanging proteins that provide a major element in the biological identity of particles. Results provide insight into the relative importance of engineered NP properties and acquired alterations of the NP in determining the biological and environmental fate of NPs over their life cycle.