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Functionalized Nanosheets Designed For Molecular Recognition
Designed and synthesized a new class of antibody-mimicking material, built from a rugged peptoid nanosheet scaffold
Significance and Impact
The functionalized nanosheets are promising for sensing and catalysis, and represent an important step toward extending the rules of protein folding to the world of synthetic materials.
- Nanosheets were formed from peptoid polymers programmed to self-assemble into an antibody-like architecture, with functional loops on the surface.
- Determined structure and assembly mechanism with AFM and XRD measurements.
- Demonstrated use of functionalized sheets as substrate for enzymes and to direct growth of gold metal.
Antibody-Mimetic Peptoid Nanosheets for Molecular Recognition. Gloria K. Olivier, Andrew Cho, Babak Sanii, Michael D. Connolly, Helen Tran, and Ronald N. Zuckermann. ACS Nano Article ASAP. (2013)