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March 2019

Multi-color Imaging with Sub-20-nm Cathodolumninescent Nanoprobes Using Electron Microscopy


Scientific Achievement

Taking advantage of a microscope detection scheme developed by Foundry staff, a team of users detected cathodoluminescence emission spectra from individual sub-20-nm nanoparticles in 9 distinct colors.

Significance and Impact

This study provides the first demonstration of functional cathodoluminescence (CL) in electron microscopy. This new detection scheme could enable a new bioimaging technology capable of resolving individual proteins and protein interactions with color coding that indicates function.

Research Details

M.B. Prigozhin, P.C. Maurer, A.M. Courtis, N. Liu, M.D. Wisser, C. Siefe, B. Tian, E. Chan, G. Song, S. Fischer, S. Aloni, D.F. Ogletree, E.S. Barnard, L-M. Joubert, J. Rao, A.P. Alivisatos, R.M. Macfarlane, B.E. Cohen, Y. Cui, J.A. Dionne, S. Chu. Nat. Nano. 2019. DOI:10.1038/s41565-019-0395-0