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Specialized Instrumentation and Expertise Available to Users

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Analytical

    1. Agilent 1100 series (ion trap) LC-MS-MS Mass spectrometer
    2. Agilent analytical HPLC
    3. CH Instruments Potentiostat
    4. Jasco Circular Dichroism Spectropolarimeter
    5. Jobin Yvon FluoroMax Fluorometer
    6. Molecular Devices Absorbance and Fluorescence Plate Readers
    7. TA Differential Scanning Calorimetry
    8. TA Isothermal Titration Calorimetry
    9. Olympus IX-81 Total Internal Reflection Microscopy System with Andor EMCCD camera
    10. Waters Acquity UPLC system
    11. Waters MALDI Synapt G2 high resolution ion mobility TOF mass spectrometer with electrospray and MALDI source capabilities
    12. Zeiss 710 Laser Scanning Confocal Microscope with upconversion capabilities

Biological

    1. Anaerobic chamber
    2. Avestin Cell Homogenizer
    3. BD Biosciences FACS Aria Flow Cytometer and Cell Sorter
    4. Beckman NxPHigh Throughput Screening Robot
    5. Cell culture incubators and biosafety cabinets
    6. New Brunswick BioFlo 310 Fermenter
    7. Real Time PCR7000 Sequence detection System

Purification

    1. Agilent prep and semi-prep HPLC’s
    2. Beckman Optima Ultracentrifuge
    3. Biotage SP1 Flash Chromatography
    4. Biotage V10 Solvent Evaporator
    5. GE Healthcare Akta FPLC
    6. GeneVac HT-4X Evaporator
    7. SP Scientific & Labconco Lyophilizers
    8. Waters Mass Selective Autopurification system (mass directed semi-prep scale HPLC)

Synthesis

    1. AAPPTec Apex 396 Peptide Synthesizer
    2. CEM Liberty Microwave Peptide Synthesizer
    3. Custom-built Robotic Combinatorial Synthesizers (2)
    4. Protein Technologies Inc. Prelude Synthesizer

Expertise

    1. Mammalian and microbial cell culture;
    2. Protein expression and purification;
    3. Phage display peptide libraries;
    4. Molecular biology techniques for DNA/RNA manipulations;
    5. Genetic engineering of cell lines for materials integration;
    6. Kinetic analysis of protein and mineral crystallization
    7. Physical & biochemical characterization of microbial surfaces
    8. Biocompatible coatings of nanomaterials;
    9. Organic fluorescent probe development;
    10. Cellular imaging with nanocrystals;
    11. Electrochemical characterization
    12. Nanocrystal development and characterization;
    13. Biopolymer synthesis analysis and purification
    14. Combinatorial library synthesis and screening.
    15. Synthesis and engineering of two-dimentional materials
    16. Design, synthesis, and folding of information-rich synthetic polymers
    17. Sequence-specific peptoid polymer-based materials