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August 2017

Mimicking Nature with Designer Molecules

Berkeley Lab’s Molecular Foundry hosted the 10th Peptoid Summit, a gathering of students, postdocs, and other researchers who are investigating new directions in biologically inspired polymer research, focusing on synthetic chains of molecules termed “peptoids.” The conference began August 10 and ends August 11.

Peptoids, or “peptide-like molecules,” are human-made versions of nature’s proteins that are highly customizable and have opened up new avenues of research in a range of fields, from biomedicine to materials science. New materials made from peptoids have the structural complexity of living systems and the durability of manufactured materials.

“We’re following nature’s example to develop functional, stable nanostructures,” said Ron Zuckermann, director of the Biological Nanostructures Facility at the Molecular Foundry. Zuckermann pioneered the field of peptoid synthesis and his team developed the first automated robotic synthesis process to facilitate their production.

The keynote address, delivered by Jonathan Clayden of the University of Bristol, highlighted how peptoids can mimick biology’s ability to encode, manipulate and communicate information across cell membranes. His research focuses on controlling the arrangement of atoms in a molecule like a light switch – in one position, the molecule is “off,” but in another, the molecule is turned “on.”

Using the structure of the protein rhodopsin, a molecule vital for human vision, as a guide, Clayden created a rhodopsin-like peptoid that when triggered by a specific chemical, emits light. He hopes to be able to use this process one day to use chemical cues outside a membrane to trigger chemical reactions within.

In hosting the Peptoid Summit at the Molecular Foundry, Lab scientists also sought to introduce visiting researchers to the facility’s capabilities. The Peptoid Summit has proven to be a fruitful place for new ideas and collaborations: A project to accurately predict peptoid structures using computer models sprang out of a past summit, for example.


Read the full press release.