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Shape-shifters: Peptoids Unexpectedly Change Shape When Forming Nanosheets
An international team led by Foundry researchers and involving three teams of users has discovered that peptoids can change shape when they form a nanosheet.
Significance and Impact
This is the first evidence that shows peptoids can change shape. With a better understanding of how peptoid chains organize themselves, this work will open the door to creating new types of durable and engineerable biomimetic nanomaterials.
- One team of Foundry users studied the atomic details of the molecular structure of a peptoid nanosheet using the Foundry's computational model in conjunction with data from solid-state nuclear magnetic resonance (NMR) spectroscopy.
- The solid-state NMR data confirmed some structural predictions, but identified some bond angles that did not match the model.
- Foundry researchers worked two other teams to create a new model which matched the data better than before, and showed that peptoids change shape when they assemble into nanosheets.
B.C. Hudson, A. Battigelli, M.D. Connolly, J. Edison, R.K. Spencer, S. Whitelam, R.N. Zuckermann, A.K. Paravastu. J. Phys. Chem. Lett. (2018). 9 (10). 2574-2578. DOI: 10.1021/acs.jpclett.8b01040 J. Edison, R.K. Spencer, G.L. Butterfoss, B.C. Hudson, A.I. Hochbaum, A.K. Paravastu, R.N. Zuckermann, S. Whitelam. PNAS. (2018) DOI: 10.1073/pnas.1800397115