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June 2018

Shape-shifters: Peptoids Unexpectedly Change Shape When Forming Nanosheets

Scientific Achievement

An international team led by Foundry researchers and involving three teams of users has discovered that peptoids can change shape when they form a nanosheet.

Significance and Impact

This is the first evidence that shows peptoids can change shape. With a better understanding of how peptoid chains organize themselves, this work will open the door to creating new types of durable and engineerable biomimetic nanomaterials.

Research Details

B.C. Hudson, A. Battigelli, M.D. Connolly, J. Edison, R.K. Spencer, S. Whitelam, R.N. Zuckermann, A.K. Paravastu. J. Phys. Chem. Lett. (2018). 9 (10). 2574-2578. DOI: 10.1021/acs.jpclett.8b01040 J. Edison, R.K. Spencer, G.L. Butterfoss, B.C. Hudson, A.I. Hochbaum, A.K. Paravastu, R.N. Zuckermann, S. Whitelam. PNAS. (2018) DOI: 10.1073/pnas.1800397115