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March 2019

High Resolution Imaging of Amorphous Structures using Cryogenic Electron Microscopy

Scientific Achievement

First demonstration of cryo-EM averaging techniques to study amorphous vesicles at the one nanometer length scale.

Significance and Impact

The sorting and averaging techniques that are commonly used to study ordered structures such as folded proteins can also be applied to study amorphous structures at high resolution.

Research Details

X. Jiang, R. Spencer, J. Sun, C. Ophus, R. Zuckermann, K. Downing, N. Balsara, J. Phys. Chem. B (2019) DOI: 10.1021/acs.jpcb.8b11752