Adapted from this Columbia press release
In 2021, lanthanide-doped nanoparticles made waves—or rather, an avalanche—when Changwan Lee, then a PhD student in Jim Schuck’s lab at Columbia Engineering, set off an extreme light-producing chain reaction from ultrasmall crystals developed at the Molecular Foundry at Berkeley Lab. Those same crystals are back again with a blink that can now be deliberately and indefinitely controlled.
“We’ve found the first fully photostable, fully photoswitchable nanoparticle—a holy grail of nanoprobe design,” said Schuck, Foundry user and Columbia associate professor of mechanical engineering.
This unique material was synthesized in the laboratories of Emory Chan and Bruce Cohen at the Molecular Foundry, Lawrence Berkeley National Laboratory, as well as in a national lab in South Korea. The research team also included Yung Doug Suh’s lab at Ulsan National Institute of Science and Technology (UNIST).
Existing organic dyes and fluorescent proteins used in applications like optical memory, nanopatterning, and bioimaging have yielded years of breakthroughs (and garnered a Nobel Prize in Chemistry in 2014), but these molecules have limited lifespans. Upon illumination, most will begin blinking randomly and ultimately will go dark permanently, or “photobleach.”
In contrast, lanthanide-doped nanoparticles show remarkable photostability. In over 15 years of working with them in his lab, Schuck noted they’ve never seen one die. Until one random day in 2018 when Lee and PhD student Emma Xu observed a crystal go dark, and then turn back on again. Lee dug into the literature and found 30-year-old mentions of lanthanide optical fibers that could be “photodarkened” and “photobrightened”—suggesting the blinking behavior could be controlled.
In a new paper published today in Nature, the team does just that. Using near-infrared light, they darkened and brightened their nanoparticles over a thousand times in different ambient and aqueous environments with no signs of degradation.
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Looking towards potential applications, the team demonstrated how the particles can be used to write—and rewrite—patterns onto 3D substrates, which could one day improve high-density optical data storage and computer memory.
“This indefinite, bidirectional photoswitching nanocrystal could yield an all-optical quantum memory device for storing the vast amount of data produced by quantum computers—think of CD-ROMs and CD-RWs, but faster and much more precise,” Suh said.
In addition to pursuing potential applications in optical memory, super-resolution microscopy, and bioimaging and biosensing, the team is using nanoparticle synthesis robots at the Molecular Foundry, advanced computational models, and machine learning to improve the current crystals further and explore whether they can synthesize other kinds of nanoparticles with similar photoswitchable properties.
This entire study was a surprise, said Cohen. “We had been saying since our 2009 paper that this class of nanoparticles doesn’t switch on and off, and yet that’s exactly what we’re studying here. One of the things we’ve found with these nanoparticles is to embrace weird results.”
Read the full press release