Staff Scientist, Imaging and Manipulation of Nanostructures
510.495.2375
Biography
Education
- 1997 University of Science and Technology Beijing, China, Ph.D., Material Physics (Mentors: Profs, Lianmao Peng, and Ke-Hsin Kuo)
- 1993 Lanzhou University, Gansu Prov., China, M.S., Theoretical Physics (Mentor: Prof. Yi-Shi Duan)
- 1990 Lanzhou University, Gansu Prov., China, B.S., Theoretical Physics
Research Interests
My research group is focused on developing a new-era electron microscopy technique, individual-particle electron tomography (IPET) for achieving 3D structure of a single macromolecule (no averaging from different molecules) at nanometer resolution. As an only experimental approach for uncovering a single macromolecular 3D structure (no averaging) at near nanometer resolution, IPET can uncover the interface between flexible macromolecules; reveal the macromolecular dynamics/fluctuations and track the 3D structural changes during chemical reactions of soft and biological macromolecules. This information is critical for current biological research and drug development, as a result, IPET will bring a large amount of users to our molecular foundry.
Selected Invited Lectures
- “Three-dimensional electron tomographic for hard and soft materials research.” Workshop talk at Materials Research Society, spring meeting, Phoenix, AZ, Workshop talk in Mar. 2017,
- “Individual-Particle Electron Tomography (IPET): an approach to study flexible soft-/bio-molecular structure and dynamics”. National Institute of Standard Technology (NIST), Gaithersburg, Maryland, U.S, Workshop talk in Mar. 2017.
- “3D image of a single protein”. National Institute of Standard Technology (NIST), Gaithersburg, Maryland, Seminar, Nov. 2016.
- “Individual-particle electron tomography (IPET): an approach to study protein mechanism, dynamics and aggregation.” 21st Annual Sealy Center for Structural Biology Symposium, Galveston, TX, April 2016
- “3D structural dynamics of DNA-nanogold conjugates.” NanoWorld Conference, Boston, MA
- “Individual-particle electron tomography (IPET): an approach to study protein mechanism, dynamics and aggregation.” The Higher Order Structure 2014, An International Separation Science Society, Long Beach, CA., March 2015
- “Individual-particle electron tomography (IPET): an approach to study protein mechanism, dynamics and aggregation.” Medical College of Wisconsin, Milwaukee, WC, March 2016
- “IPET: an approach to study protein mechanism, dynamics and aggregation.” Eli Lilly, Indianapolis, IN, October 2015
- “Individual-particle electron tomography (IPET): an approach to study protein mechanism, dynamics and aggregation.” Eli Lilly, San Diego, CA, August 2015
- “Individual-particle electron tomography (IPET): an approach to study protein mechanism, dynamics and aggregation.” Biogen Inc., Boston, MA, July 2015
