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Molecular Foundry

HIGHLIGHTSA Comprehensive Model for Molecular-Bond Formation and Rupture
July 2, 2012

Force spectra of ten different kinds of molecular bonds show transition from near-equilibrium to a kinetic regime. Inset, data re-plotted on the natural axes that emerge from the model show that it provides a universal description of bond breaking across the two regimes.
  • Developed a new model for interpreting molecular-bond force spectra and verified it with measurements of ten different molecular systems
  • Resolves inconsistencies in the standard model and provides a comprehensive description of bond formation and rupture
  • Enables prediction of binding free energy of a molecular system, important for both understanding interactions in natural systems and designing synthetic analogues
R.W. Friddle, and J.J. De Yoreo, Lawrence Berkeley National Laboratory; A. Noy, Lawrence Livermore National Laboratory. “Interpreting the widespread nonlinear force spectra of intermolecular bonds.” Proceedings of the National Academy of Sciences 109, 34 (2012).

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