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Molecular Foundry

HIGHLIGHTSMultimeric Chelating Peptoids for Selective Metal Coordination
October 26, 2019

Figure illustrating the combinatorial nature of the ligand library. Each of the tested metal-binding units is represented as a red or blue claw. 16 octadentate peptoid combinations were obtained with 2 bidentate metal-binding synthons.

Scientific Achievement

Foundry users created a new library of tetrameric peptoid ligands that can be used for the chelation of radioactive f-block metals.

Significance and Impact

The peptoid library provides a high-throughput method for the precision design of new specific and versatile multidentate ligands for applications in a variety of fields including medicine, defense, and optics.

Research Details

  • The researchers incorporated high-affinity metal binding units onto peptoid scaffolds at the Molecular Foundry. They used custom-made sub-monomers known for their f-element binding properties.
  • Luminescence-based coordination studies on the resulting ligands with Eu+ and Tb3+ revealed a variety of spectroscopic properties and complex stability.
  • Both ligand systems show high affinity for Ln(III) metals with stability constants greater than 1029 for Eu3+ with the investigated chelators.
A. Ricano, I. Captain, K.P. Carter, B.P. Nell, G.J.-P. Deblonde, R.J. Abergel. Chemical Science 2019 10, 6834. DOI: 10.1039/c9sc01068h

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