Foundry users created a new library of tetrameric peptoid ligands that can be used for the chelation of radioactive f-block metals.
Significance and Impact
The peptoid library provides a high-throughput method for the precision design of new specific and versatile multidentate ligands for applications in a variety of fields including medicine, defense, and optics.
- The researchers incorporated high-affinity metal binding units onto peptoid scaffolds at the Molecular Foundry. They used custom-made sub-monomers known for their f-element binding properties.
- Luminescence-based coordination studies on the resulting ligands with Eu+ and Tb3+ revealed a variety of spectroscopic properties and complex stability.
- Both ligand systems show high affinity for Ln(III) metals with stability constants greater than 1029 for Eu3+ with the investigated chelators.